Osmotic Fragility of Human Erythrocytes is Altered by Porphyrin Compounds

The chemical specificity of Porphyrin derivatives, Tetraphenylporphinesulfonate (TPPS), 5, 10, 15, 20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron (III) Chloride (FeTPPS) and 5, 10, 15, 20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron (III) nitrosyl Chloride (FeNOTPPS), on osmotic fragility of erythrocytes was examined in vitro. TPPS increased the osmotic fragility of erythrocytes more effectively in hypotonic PBS solution. Incorporation of iron and nitroso group in the Porphyrin ring decreased the effectiveness. The results showed that the size, form and elements introduced into the Porphyrin compound affected its affinity to the cell membrane, and changed the osmotic resistance in erythrocytes.